First IVF baby born after new technique to eliminate genetic disease

by Rachel Brown, April 13, 2015 – bionews.org

The first baby in Europe has been born following a new IVF-based technique developed to prevent the inheritance of genetic disease.

The screening technique, called karyomapping, is a type of PGD (preimplantation genetic diagnosis) procedure. Current PGD methods are developed on a case-by-case basis to test embryos for the presence of a specific mutation found in one or both of the parents’ DNA and can involve months of laboratory work.

Karyomapping, on the other hand, can test for the same diseases, but can be completed much faster and is no more expensive than traditional PGD methods. It can also be used to check that embryos have the correct number of chromosomes.

Mrs Carmen Meagu suffers from Charcot-Marie-Tooth disease, a group of rare disorders of the peripheral nervous system that cause muscle degeneration and sensation loss in the feet and hands. She inherited the disease from her father, and had a 50 percent chance of passing it on to her children.

Speaking to The Telegraph, Mrs Meagu said: ‘For me the risk was too high. I was told I could try and get pregnant and have a test at 16 weeks, but that really wasn’t an option for me because it would have been too hard to have an abortion at that stage.

‘Then we were told about a clinic in London which could screen the disease out, and we felt we had to try’.

The technique involves using DNA from Mrs Meagu, her husband Gabriel, and another family member, to compare roughly 300,000 different points across the genome called SNPs (single nucleotide polymorphisms). This allows scientists to find characteristic features that are unique to the chromosome carrying the defective gene. Following a standard IVF cycle, embryos are biopsied to find out which ones are free of the genetic disease.

Mr Paul Serhal is the founder and medical director of the Centre for Reproductive and Genetic Health, where the technique was used in December 2013. Also speaking to The Telegraph, he explained: ‘Essentially, karyomapping finds a fingerprint that is unique to the chromosome that carries the defective gene.

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China to crack down on surrogacy industry

Xinhua News Agency,

BEIJING, April 9 (Xinhua) — China will launch a nationwide cross-department campaign to crack down on illegal surrogacy starting this month.

The nine-month campaign will last until the end of this year and will involve 12 government departments focusing on spotting and punishing medical personnel and intermediary agencies that help perform surrogate pregnancy services, the National Health and Family Planning Commission (NHFPC) announced Thursday.

Internet website, TV, radio and print media that carry surrogacy ads will also be cleansed, while the authorities will step up supervision over the sale and circulation of assisted reproductive technology (ART) drugs and medical equipment, it said.

Surrogacy is strictly banned in China, but the wombs-for-rent businesses has thrived in the world’s most populous country, where some studies indicate an estimated one in eight couples face fertility problems.

Click here to read the entire article.

The Hague has decided to appoint an expert group to meet early next year to look at private international rules concerning children, including surrogacy

March 30, 2015 via Stephen Page

The Council decided that an Experts’ Group be convened to explore the feasibility of advancing work in this area . The Experts’ Group should first consider the private international law rules regarding the legal status of children in cross-border situations, including those born of international surrogacy arrangements. To this end, the Council decided that:

a)  the Experts’ Group should meet in early 2016 and report to the 2016 Council;

b)  the Group should be geographically representative and be composed in consultation with Members; and

c)  members are invited to keep the Permanent Bureau updated regarding significant developments in their States in relation to legal parentage and surrogacy.

 

Click here to read the press release.

Kids thrive just as well in non-traditional families, new book says

MyKwartha.com, March 20, 2015 – By Andrea Gordon

Baby Jasmine Chan delivered the ultimate Valentine’s Day gift to her parents this year. It was her first word, clear and deliberate.

“Daddy,” she said, beaming across the dinner table.

Music to her two dads’ ears.

When they met 12 years ago, Paul Chan and Ewan French never imagined they would one day answer to Daddy or Papa.

Chan had recently come out to his family. It was a tough period and his mother was heartbroken. She wanted grandkids. He assumed his own dream of being a father would never come true.

It wasn’t until they married two years ago that the couple started to explore the idea of parenthood. Chan, 33, was confident they could be good, loving parents. French was on the fence.

“I always knew we’d have a strong community around us,” says French, 34, who was born and raised in Scotland.

“But I didn’t want (our child) to face any challenges because of having same-sex parents. Would we be putting her at an unfair advantage because of it?”

According to a new book from University of Cambridge developmental psychologist Susan Golombok, the answer is a resounding “No.”

Golombok, director of the university’s Centre for Family Research, has been studying the impact of evolving family structures on children for almost 40 years.

Modern Families: Parents and Children in New Family Forms, which rounds up research from around the world, concludes that children raised by same-sex parents and solo moms by choice or born as a result of donor conception or surrogacy fare just as well as kids raised by a two-parent, heterosexual married couple.

“The main conclusion is that what matters for children is not so much the structure of the family — the gender or sexual orientation of their parents, the number of parents or whether parents are biologically related to their children,” Golombok said in a phone interview from England.

“What seems to be more important is the quality of the relationships within the family.”

In other words, while the traditional model of mom, dad and biological kids was once considered “the gold standard,” four decades of research doesn’t bear that out.

All other things being equal, children manage just as well — and face the same difficulties — whether they have two dads and no mom, or two moms and no father as they do with two heterosexual parents. There is no evidence they have more psychological problems, difficulty adjusting or atypical gender development, Golombok found.

The fluidity of partnerships and family is also the subject of a soon-to-be-released book by Hollywood actress Maria Bello.

Her memoir, Whatever…Love is Love, follows her 2013 Modern Love column in the Sunday New York Times, which drew accolades. Titled “Coming Out as a Modern Family,” it told the poignant story of how Bello explained to her 12-year-old son that she was in love with her best friend, a woman.

The piece, which made the list of the top 10 Modern Love columns ever written, highlights the resilience and adaptability that kids can demonstrate when they have trusting relationships with parents.

It’s something Chantal Saville has seen in her 6-year-old daughter Nikki, who she’s now raising with the help of her own mom.

After Saville’s marriage broke up two years ago and the couple sold the business they ran outside Peterborough, she wondered how she’d make ends meet.

Her mother, widowed a decade earlier, was still living in the Toronto bungalow Saville grew up in as an only child. The two had always been close.

“Now we are effectively co-parenting Nikki,” says Saville, 42, a writer.

In the early days, mom and grandma occasionally locked horns over discipline when the era of, “because I said so” clashed with modern refrain of, “sweetie, here’s why I need you to do what I ask.”

But they’ve learned that communication is key and that whoever is in charge at a given moment gets the final word.

Organizations like American Academy of Pediatrics and the American Psychological Association have already endorsed findings that the sexual orientation of parents has no bearing on child-rearing abilities or the well-being of kids.

What’s new about Modern Families is it brings together empirical research involving many thousands of families from around the world and explores some of the reasons that more unorthodox families seem to do so well.

Golombok’s career has spanned an evolution in family life, starting in the late 1970s as lesbian moms came out and divorced husbands fought for the right to raise their children, followed by the arrival of the first test-tube baby in 1978.

The book comes amid a huge shift in how society recognizes and accommodates the assortment of families created as a result of assisted reproductive technologies. Modern kids may have a “solo mom” who chose to have a child on her own using donated sperm, or relationships with as many as five parents, including two legal parents, a sperm donor, egg donor and a surrogate.

The careful planning and lengths these parents go to in order to have children may be one reason their kids do well, says Golombok.

It can require years of fertility treatment and facing other barriers like social disapproval. The less motivated give up along the way.

Click here to read the entire article.

Surrogacy and the ‘Legal Parent’ in the UK

 

GayStarNews.com – March 10, 2015

Gemma Whitchurch, of family law solicitors, Irwin Mitchell, looks at some if the legal issues around surrogacy for those in the UK.  Surrogacy is when another woman carries and gives birth to a baby for the couple who want to have a child. For many childless couples and same sex partners it can enable them to have a baby when it would otherwise have been impossible.

There are two types of surrogacy: 1. Full surrogacy (also known as host or gestational). This involves the implantation of an embryo created using either: • the eggs and sperm of the intended parents; • a donated egg fertilized with sperm from the intended father; or • an embryo created using donor eggs and sperm. 2 Partial surrogacy (also known straight or traditional). This involves sperm from the intended father and an egg from the surrogate. Here fertilization is usually undertaken by artificial insemination or intrauterine insemination. If you are considering a surrogacy arrangement, it is crucial to take legal advice before you embark on the process.

The law in this area can be quite complex and unless a parental order is made then the child’s legal parents may not be as you intended. It is important to note that commercial surrogacy is illegal in the UK and as such is a criminal offence. Surrogacy agreements cannot be enforced and therefore caution should be given to anything that purports to be a surrogacy contract. Under the law of England and Wales, irrespective of a biological connection, the woman who gives birth to the child is the child’s mother. This means that even if the child was conceived using the egg of another woman, the woman who gives birth will be the child’s legal mother.

The position of the ‘other parent’ is much more complex and varies whether the surrogate mother is married or unmarried, and in the case of the latter, whether the treatment takes place at a licensed clinic. To realign parentage in a surrogacy arrangement, the intended parents must apply for a parental order. The effect of a parental order is to give the commissioning parents the status of legal parents in the ordinary way.

The Human Fertilization and Embryology Act provide that applicants for a parental order must be: a) Husband and wife; b) Civil partners; or c) Two persons who are living as partners in an enduring family type relationship and are not within prohibited degrees of separation of each other. Surprisingly this has not yet been amended to specifically allow for those applicants in a same-sex marriage, although one cannot envisage any problems if they were to apply for a parental order. The only category of person excluded from applying for a parental order is a single parent which is in stark contrast to adoption where there can be a single applicant. However, it is important to note that this does not stop a single parent entering into a surrogacy arrangements, whether in this country or abroad. In such a situation, legal advice should always be obtained. To make a parental order two conditions must be satisfied: a) The child must have been carried by a woman who is not one of the applicants, AND b) The gametes of at least one of the applicants must have been used to create the embryo

The application must be made within six months of the child being born.  However, there has been a case whereby the application was successful despite being made two years after the child’s birth. In such circumstances, every case will be fact specific and in considering any application for a parental order the welfare of the child will always be the court’s paramount consideration.

Click here to read the entire article.

IVF test improves chances of implantation by pinpointing fertility window

March 10, 2015 – the guardian.com

Thousands of infertile couples could benefit from a new test that tailors the timing of IVF treatment to a woman’s individual cycle for the first time.

The scientists behind the technique believe that IVF frequently fails because the embryo is transferred at the wrong time, missing a crucial fertility window.

The new test assesses the activity of genes of the womb lining to pinpoint a woman’s optimum time for treatment and in pilot studies the personalised approach appeared to significantly boost success rates.

Prof Juan Garcia-Velasco, of the IVI fertility clinic in Madrid, said: “We think that about 15% of cases of implantation failure are simply due to bad timing.” Prof Garcia-Velasco is now leading a clinical trial of the test, involving 2,500 patients in more than ten countries, including Britain.

Geeta Nargund, medical director of Create Fertility whose London clinic is participating, said: “The weakest link in IVF is implantation failure. I believe this is a breakthrough.”

There are more than 60,000 IVF cycles in Britain each year, but just 24% of these treatments lead to live births. Clinics currently check the visual appearance of the womb lining using ultrasound, giving a general indication of health.

“What we have never known is the right window of implantation,” said Nargund. “If you miss that window, no matter how beautiful the embryo, it’s not going to implant.”

For most women there is a two to four day stretch when the lining, or endometrium, sends out crucial chemical signals that allow the embryo to attach. For some women the fertile window is shifted earlier or later in the cycle or is unusually brief, however.

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Thailand bans commercial surrogacy

TheGuardian.com – February 24, 2015

Thailand’s parliament has passed legislation banning commercial surrogacy, putting a halt on foreign couples seeking to have children through Thai surrogate mothers.

The issue of surrogacy was in the spotlight in Australia last year after a Western Australian couple were accused of leaving a twin boy, known as Baby Gammy, with his surrogate mother after they discovered he had Down syndrome.

The legislation passed by Thailand’s national legislative assembly on Thursday closed loopholes in the country’s public health laws that enabled commercial surrogacy to thrive.

The new law bans all foreign and same-sex couples from seeking surrogacy services in the country.

Only married heterosexuals with at least one Thai partner are allowed to use surrogates. There are no fees allowed for the service and the surrogate mothers must be Thai and over 25 years old.

The surrogate mothers are also required to be relatives of either the husband or wife.

The legislation also includes a ban on advertising and promotions, and shuts down surrogate agents and unregistered clinics.

The Baby Gammy case made headlines in August 2014 when Thai surrogate Pattaramon Chanbua alleged West Australian couple Wendy and David Farnell had abandoned Gammy and returned to Western Australia with his healthy twin sister, Pipah.

Farnell, a convicted child sex offender, retained custody of Pipah late last year after an investigation by the WA Department for Child Protection.

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Gay couple stuck in Mexican legal limbo after birth of surrogate twins

El Pais – Mexico City 12 FEB 2015

Luis Delgado and José Antonio Fernández, a gay married couple from Spain, decided to have a child via a surrogate mother in Mexico. Their twins were born on January 6, but the four of them have found themselves unable to return together to their home country.

Due to a legal anomaly, they cannot secure passports for their children, given that the state of Tabasco, Mexico, where the surrogacy took place, recognizes surrogate births, while the Secretariat of Foreign Affairs (SRE) – the government department responsible for Mexican passport applications – does not.

The couple say they have heard “very positive words” from the Spanish authorities, but nothing more.

It is illegal for couples to have children via surrogates in Spain, but if the country where the surrogacy takes place officially confirms that the couple (whether they are homosexual or heterosexual) are the biological parents of the children in question, they can be registered in Spain and obtain Spanish passports. If not, the mother must appear on the paperwork. But Delgado and Fernández cannot produce an acceptable version of that certificate for the authorities.

The pair signed a surrogacy contract in Mexico last year, and when the babies were born they registered them in Tabasco with José Antonio as the father, and on another part of the form, Luis as the other parent. The part of the form where the mother should have appeared was left blank.

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AG recommends recognizing same-sex parents in Israel

ynetnews.com, February 9, 2015 by Aviel Magnezi

Israel takes step towards granting parental rights to same-sex parents, as AG says state should give recognize partner of biological parent, instead of forcing them to legally adopt child.

Attorney General Yehuda Weinstein submitted a precedent-setting request to the family court on Sunday, recommending that the same-sex partner of a biological birth mother be regarded as a legal parent.

The recommendation pertains to same-sex parents of a child born through sperm donation. Currently, the non-biological partner was forced to adopt their partner’s biological child in order to be listed as a legal parent.

In 2003, the Supreme Court ruled that the partner of a biological parent can be registered as the child’s parent in the civil registry, following a US court ruling that ordered to allow the names of a same-sex couple on birth certificates.

 

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Adoption hope for same-sex couples in Bermuda

February 6, 2015 – The Royal Gazette By Owain Johnston-Barnes

Unmarried and same-sex couples can apply to jointly adopt children, according to a recent judgment in the Supreme Court.

Under the Adoption Act 2006, unmarried couples have been unable to jointly adopt children. Bermuda does not recognise same-sex marriage, so the Act also indirectly banned same-sex couples from joint adoption.

But in a judgment dated February 3, Puisne Judge Stephen Hellman ruled that section of the Act represented unlawful discrimination.

The ruling came after an unnamed same-sex couple wanted to adopt a nine-month-old child they had been raising together.

They were told by the Department of Child and Family Services (DCFS) that, as an unmarried couple, they would have to make separate applications, which would be processed and considered separately. The couple argued that requiring a separate process was discriminatory and sought a declaration from the Court that the Adoption Act should be read in a manner which is consistent with the Human Rights Act, which forbids discrimination on the grounds of marital status and sexual orientation.

The department argued that having the couple processed separately would not constitute less favourable treatment. In the judgment, Mr Justice Hellman found that “marital status” included both the state of being married and unmarried.

“If one is a status so, too, is the other,” he stated. “Permitting a joint application by a married couple but not an unmarried couple is discriminatory in that it involves treating the unmarried couple less favourably than the married couple by providing adoption services to the one couple but not the other.

“For the reasons given by the plaintiffs, I therefore reject the defendants’ submission that processing the plaintiffs’ applications separately, with the possibility of a separate adoption order in the case of each plaintiff, would not constitute less favourable treatment.

“It would, however, constitute a refusal to provide them with adoption services of a like quality, in the like manner and on the like terms on which the DCFS normally makes them available to other members of the public, namely applicants who are married couples.

“It is in any case doubtful whether the Act would permit the court to entertain two applications for the adoption of the same child.

“The argument that it would involve a strained construction of the statutory language to which a court would likely only have recourse if it were necessary to avoid applying that section in an unlawfully discriminatory way.

“As it would not achieve that end, there is no good reason to construe the section in this way.”

He ruled that the statutory ban on the couple to adopt was unlawful, noting that the same position had already been taken by courts in Britain, Canada, Gibraltar, and South Africa.

Click here to read the entire article.